Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.
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The dome matrix technology described in Table 3 was developed by Losi and co-workers. The same concept has been demonstrated in a patent by Kim and co-workers where the system provided release of two drugs in different manners.
The release profiles obtained demonstrated that drug release was slower from the multilayered tablets than from the core tablet alone [ 40 ]. Geolock TM Technology Geolock TM Technology is a triple layered tablet that has been devised for chronotherapy focused-real geomatix oral drug delivery [ 85 ]. Retention and distribution in human head and neck squamous cell carcinoma xenograft model. A textural analysis study.
The tablets also proved to be feasible to manufacture on twchnology larger scale.
Geomatrix Technology – Oral Drug Delivery – Doctor Steve Abel
Bimodal drug release achieved with multi-layer matrix tablets: Thus far researchers have attempted to control dissolution behavior of drug delivery systems by modifying and controlling the geometry of the employed devices e. The bilayered tablet consisted of a core tablet where one surface was covered with either Cellulose Acetate Phthalate CAP or Methocel E50LV, while both surfaces of the core tablet were covered with both of the polymers to form the triple-layered tablets [ geokatrix ].
Various arrangements of modules to form different structures.
A multi-layered controlled release tablet containing naproxen and naproxen sodium salt was developed by Desai in Various arrangements of modules to form different structures Arrangement of modules, type of polymeric material used. These tablets were comprised of an immediate release layer and a sustained release layer.
This type of delivery may be beneficial for preventing tolerance arising from the drug as well as in reducing the side-effects. Bilayered tablets have proven to be effective in delivering drugs that require a loading dose followed by a maintenance dose [ 80 — 83 ].
These geometric manipulations may also be employed to develop drug delivery systems for the treatment of specialized biological conditions where zero-order drug release is not optimal, for example chronotherapy for heart conditions [ 46 ] or the scheduled treatment of asthma and inflammation [ 47 ].
This technology has proven to be useful as it does not require specialized polymers to goematrix the desired function. Donut-Shaped Devices for Controlled Drug Delivery There are various publications dating rather far back that established that zero-order release kinetics could be achieved from a hemispherical device containing a hole [ 4245— ].
This review focuses on the geometric technology that had been developed to provide controlled release of drugs. The efficiency of cup tablets with varying depths and the optimal formulation in terms of drug release were investigated in the study.
Core-in-Cup Devices Danckwerts developed a core-in-cup tablet system that was able to provide zero-order drug release of aqueous-soluble and aqueous-insoluble drugs.
The results indicated that Ibuprofen was released at a near zero-order rate for 18 hours for the cup tablets that had a final depth of 4 mm [ 99 ]. Preparation of bilayer-core osmotic pump tablet by goematrix the indented core tablet. With chronotherapy, drug release is governed by time so that drug is released only when needed in accordance with the circadian rhythms of the body. It was discovered that by increasing the weight of the barrier layers from 50 mg geomatrlx mg it resulted in a more effective retardation of drug release, thus it was concluded that by manipulating the weight and thickness of the outer layers as shown in Table 2 a desirable drug release profile of individual drugs may be achieved, thus complementing their pharmacokinetic behavior [ 69 ].
When the solvent penetrates the core layer, the core swells and dissolves, this causes the coating shell to break thereby rapidly releasing the drug [ 4 ].
Article | Geomatrix Technology: A Short Review | Inventi Journals
The controlled release layer delivered metformin while the rapid release layer delivered glimepiride. Generally, HPMC devices presented with slower drug release when compared to CAP devices, the reason being that they form a more efficient and solid barrier.
Table 3 Summary of various technologies that utilize geometric factors in drug delivery. It consists of a hydrophilic matrix core, containing the active ingredient and one or two impermeable or semi-permeable polymeric coatings geomatgix applied on the core.
Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery
Biodegradable polymers in controlled drug delivery. Core-in-cup devices Disc-shaped core compression coated on one surface and circumference to form a cup around it. The controlled release society; These polymers twchnology as barriers to control drug release.
Coupling of diffusion and relaxation. The release was dependent on the thickness of the layers and polymers used. They provide a geomattix pulsed profile that offers the patient efficacy throughout the day negating the need for taking the dose during working hours unlike the twice-daily dosing of the conventional immediate release tablet [ 71 ].